VMAT and TomoTherapy TBI, TMI and TMLI –
whole-body irradiation in the 21st century
Radiotherapy during myeloablative conditioning for stem cell transplantation, highly conformal planning techniques
Myeloablative Total Body Irradiation (TBI) has since long been a cornerstone of the conditioning for hematopoietic stem cell transplantation (HSCT). Currently, use of TBI is mainly indicated for high-risk hematologic malignancy with allogeneic HSCT. The aspiration to reduce acute and long-term effects has induced changes in HSCT and TBI protocols over time. Institutions have varying site-specific setups and techniques for conventional TBI. An increasing number of centers are implementing highly conformal techniques with VMAT or TomoTherapy. Total Marrow Irradiation (TMI), Total Lymphoid Irradiation (TLI), and Total Marrow and Lymphoid Irradiation (TMLI) target the bone marrow and/or lymphoid volume while reducing doses in the remainder of the body, thereby optimizing the balance between treatment outcome and toxicities.
In the 2025 VMAT and Tomotherapy TBI Teaching Symposium, international experts who have cooperated in the establishment of protocols and scientific publications will take the floor to give presentations regarding current and future perspectives for highly conformal radiotherapy techniques during myeloablative conditioning for HSCT in children and adults. The program will cover diverse aspects of implementation of VMAT and TomoTherapy TBI, TMI and TMLI treatments. There will be breakout sessions for physicists, radiotherapy technologists and radiation oncologists, where we will provide an in-depth focus on technical and clinical aspects of VMAT and TomoTherapy planning and treatment for TBI, TMI and TMLI, for different treatment planning systems and treatment machines.
Moreover, there will be ample room for connection and discussion with international colleagues to exchange experiences during the daytime program and social gatherings on June 16 and 17.
The TBI symposium is of interest for radiation oncologists, medical physicists, radiotherapy technologists, hematologists and anybody with an interest in TBI, TMI and TMLI. We hope to welcome you in Utrecht in June 2025!
Faculty
Bianca Hoeben
MD PhD, radiation oncologist
UMC Utrecht / Princess Máxima Center,
The Netherlands
Enrica Seravalli
PhD, clinical physicist
UMC Utrecht, The Netherlands
Mirjam Willemsen-Bosman
radiation technologist
UMC Utrecht, The Netherlands
International faculty
Jeffrey Wong
Professor, MD, radiation oncologist
City of Hope, Duarte, California, USA
Chunhui Han
Clinical Professor, PhD, clinical physicist
City of Hope, Duarte, California, USA
Susan Hiniker
Associate Professor, MD, radiation oncologist
Stanford University, Stanford, California, USA
Nataliya Kovalchuk
Clinical Professor, PhD DABR, clinical physicist
Stanford University, Stanford, California, USA
Jacob Engellau
MD PhD, radiation oncologist
Skåne University Hospital, Lund, Sweden
Per Engström
PhD, clinical physicis
Skåne University Hospital, Lund, Sweden
Cynthia Aristei
Professor, MD PhD, radiation oncologist
University of Perugia and Perugia General Hospital, Perugia, Italy
Simonetta Saldi
MD PhD, radiation oncologist
University of Perugia and Perugia General Hospital, Perugia, Italy
Claudio Zucchetti
clinical physicists
University of Perugia and Perugia General Hospital, Perugia, Italy
Christian Fulcheri
clinical physicists
University of Perugia and Perugia General Hospital, Perugia, Italy
Program (preliminary)
- Day 1
- Day 2
| 08.30 – 09.00 | Welcome and registration | |
| 09.00 – 09.15 | Welcome | Faculty |
| 09.15 – 09.45 | Conformal techniques for TBI; why? General introduction | Bianca Hoeben Susan Hiniker |
| 09.45 – 11.00 | Implementation of VMAT or TomoTherapy TBI / TMI / TMLI in your department; the commissioning process | Enrica Seravalli Chunhui Han Per Engström |
| 11.00 – 12.00 | Patient positioning & simulation for conformal VMAT or TomoTherapy whole-body irradiation | Mirjam Bosman Nataliya Kovalchuk Claudio Zucchetti Christian Fulcheri |
| 12.00 – 13.00 | Lunch | |
| Split up into VMAT (1) & Tomotherapy (2) groups | ||
| 13.00 – 14.00 1. auditorium | Planning basics: VMAT TBI and TM(L)I | Nataliya Kovalchuk Chunhui Han Mirjam Bosman |
| 13.00 – 14.00 2. Van Peperzeel room | Planning basics: Tomotherapy TBI and TM(L)I | Per Engström Claudio Zucchetti Chunhui Han |
| Plenary session | ||
| 14.00 – 15.00 | Treatment delivery; QA, positioning, IGRT for VMAT and Tomotherapy | Enrica Seravalli Chunhui Han Per Engström Jacob Engellau |
| 15.00 – 15.30 | Delineation for TBI and TMI and TMLI | Bianca Hoeben Simonetta Saldi Jeffrey Wong |
| 15.30 – 15.50 | Coffee/Tea, meet&greet | |
| 15.50 – 16.30 | Experience with TMI and TMLI studies in a center: City of Hope | Jeffrey Wong |
| 16.20 – 17.00 | Experience with VMAT TBI in a center: Stanford | Susan Hiniker |
| 19.00 – 22.30 | Social Dinner in Utrecht city center; Humphrey’s; Restaurant Humphrey’s Address: Stadhuisbrug 3, Utrecht |
| 08.15 – 08.45 | Coffee/Tea, meet&greet | |
| 08.45 – 09.15 | Patient pre-treatment evaluation and per-treatment monitoring for TBI, TMI and TMLI | Bianca Hoeben Simonetta Saldi Jeffrey Wong |
| 09.15 – 09.35 | Experience with TMI in a center: Lund | Jacob Engellau |
| 09.35 – 09.55 | Experience with TMLI in a center: Perugia | Cynthia Aristei |
| Breakout sessions 1+2; in-depth interactive sessions for 1) physicists / RTT and 2) clinicians | ||
| 10.00 – 12.30 1. auditorium | TomoTherapy planning + treatment | Per Engström Claudio Zuchetti Chunhui Han |
| Planning + treatment with Eclipse for Varian Linac | Nataliya Kovalchuk | |
| Planning + treatment with Monaco for Elekta Linac | Mirjam Bosman Enrica Seravalli |
|
| 10.00 – 12.30 2. Van Peperzeel room | Clinical aspects; TBI indications / outcomes / toxicity / considerations for dose+fractionation / radiobiology / GVHD / standardized reporting / conformal TBI and department burden | Bianca Hoeben Susan Hiniker |
| Clinical aspects; TMI indications / outcomes / toxicity / considerations for dose+fractionation / boost indications / long-term follow up | Jacob Engellau | |
| Clinical aspects; TMLI indications / outcomes / toxicity / considerations for dose+fractionation / GVHD / age considerations / extramedullary recurrence risk / chemotherapy conditioning / delineation | Cynthia Aristei Simonetta Saldi Jeffrey Wong |
|
| 12.30 – 13.30 | Lunch | |
| 13.30 – 14.30 | Continuation breakout sessions | |
| 14.30 – 15.30 | Interactive discussions in breakout-sessions. Meanwhile per group of 20 people: In-room demonstration rotatable tabletop patient setup. | |
| Plenary | ||
| 15.30 – 16.00 | Plenary; summary, last questions & goodbye | Whole faculty |
Practical information
Location
UMC Utrecht Cancer Center
Heidelberglaan 1003
3584 CX Utrecht
The Netherlands
Hotel Information
See the official hotel service page for the symposium
Contact
If you have any questions regarding the meeting, please don’t hesitate to contact us via:
info@tbisymposium.nl
Travel
To Utrecht
Travel to Utrecht Central Station from Amsterdam Schiphol Airport by train. Plan your journey
In Utrecht
Regular tramlines (line 21+22) and bus lines connect the city center to the hospital.
You can exit the tram / bus at stops
UMC Utrecht or WKZ / Máxima
UMC Utrecht
The symposium takes place in the Auditorium, first floor in the Q-building, room Q.01.226;
and the Van Peperzeel room. The auditorium is reached when entering the UMC Utrecht main entrance via the first floor. Follow the sign to
the Q-building. Or take the entrance in the Q building in the department of Radiotherapy, reception 2, at Universiteitsweg, and go to the first floor.
Accreditation
The Title: VMAT and TomoTherapy TBI, TMI and TMLI – whole-body irradiation in the 21st century. Subtitle: Radiotherapy during myeloablative conditioning for stem cell transplantation, highly conformal planning techniques, Utrecht, The Netherlands, Netherlands 16/06/2025 – 17/06/2025, has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 11.5 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.
Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at https://dhub.ama-assn.org/pages/applications. Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.
The European Board for Accreditation in Medical Physics (EBAMP) has been set up by medical physics societies across Europe represented by the European Federation of Organisations for Medical Physics (EFOMP). This course has been accredited by EBAMP as a CPD event for Medical Physicists at EQF Level 7.
Liability
The organizers are not liable for any losses, accidents or damage to persons or objects, regardless of the cause. Participants and accompanying persons attend the conference and all accompanying events at their own risk and responsibility.
Refund & cancellation policy
Refund policy: Registration cancellations or substitutions must be received by email to info@TBIsymposium.nl before the 26th of May 2025.
No registration refunds will be granted after that date; however, you may transfer your registration to a colleague.
Refunds will be granted after the TBI symposium.
Registration
Endorsed by
