Total Body Irradiation: from 2D to 3D and beyond

Radiotherapy during myeloablative conditioning for stem cell transplantation, current and future perspectives

Myeloablative Total Body Irradiation (TBI) has since long been a cornerstone of the conditioning for hematopoietic stem cell transplantation (HSCT). Currently, use of TBI is mainly indicated for high-risk hematologic malignancy with allogeneic HSCT. The aspiration to reduce acute and long-term effects has induced changes in HSCT and TBI protocols over time. Institutions have varying site-specific setups and techniques for conventional TBI. Several centers have introduced highly conformal techniques such as VMAT or TomoTherapy. Total Marrow Irradiation (TMI), Total Lymphoid Irradiation (TLI), and Total Marrow and Lymphoid Irradiation (TMLI) target the bone marrow and/or lymphoid volume while reducing doses in the remainder of the body.

While techniques may vary from center to center, several considerations regarding setup, total dose, fractionation and organ shielding are of interest to all specialists who perform TBI. The scarcity of guidelines and low number of treated patients in most centers makes international collaboration and knowledge exchange valuable.  

In the 2023 TBI Symposium, international experts who have cooperated in the establishment of protocols and scientific publications will take the floor to give in-depth presentations regarding current and future perspectives for conventional and highly conformal radiotherapy techniques during myeloablative conditioning for HSCT in children and adults. The program will cover clinical, technical and biological issues and considerations that are relevant for the daily practice and ongoing strive for improvement of techniques. Moreover, there will be ample room for connection and discussion with international colleagues to exchange experiences during the daytime program and social gatherings on June 5 and 6.

The TBI symposium is of interest for radiation oncologists, medical physicists, radiotherapy technologists, hematologists and anybody with an interest in TBI. We hope to welcome you in Utrecht in June 2023!



12.00-13.00Welcome, Registration and Lunch
13.00-13.05WelcomeBianca Hoeben, Utrecht, The Netherlands
13.05-13.25History of HSCT and TBIMarc Bierings, Utrecht, The Netherlands
13.25-13.45Toxicity profiles of TBI, considerations for mitigationBianca Hoeben, Utrecht, The Netherlands
13.45-14.15Clinical aspects of conventional TBI approaches and recommendationsTom Boterberg, Ghent, Belgium
14.15-15.00Technical aspects of conventional TBI approaches and recommendationsRuud van Leeuwen, Nijmegen, The Netherlands
15.00-15.30Coffee/Tea, meet&greet
15.30-16.30VMAT TBI: practical steps from the drawing board to the linacBianca Hoeben, Enrica Seravalli, Mirjam Willemsen-Bosman, Utrecht, The Netherlands
16.30-17.15VMAT and Tomotherapy TBI and TMLI: single center experience in >400 pediatric patientsDaria Kobyzeva, Anna Loginova, Moscow, Russia*
19.30Social Dinner Bar Brasserie Bren, Utrecht city center


08.00-08.30Coffee/Tea, meet&greet
08.30-09.30TMI and TMLI: clinical studies and experienceJeffrey Wong, Duarte, CA, USA*
09.30-10.30Radiobiological issues of TBI and TMI; translational and clinical studiesSusanta Hui, Duarte, CA, USA*
10.30-11.00Coffee/Tea, meet&greet
11.00-11.20Single center experience with TomoTherapy TMIJacob Engellau, Lund, Sweden
11.20-11.40Single center experience with VMAT TLIAbrahams Ocanto, Madrid, Spain
11.40-12.10TMLI in the conditioning regimen for T-cell depleted hematopoietic stem cell, regulatory and effector T-cell transplantation for acute leukemia. The Perugia experience.Cynthia Aristei, Simonetta Saldi, Perugia, Italy
12.10-12.40Group discussion: next steps – the future of radiotherapy in HSCT conditioning, collaboration, research needsDiscussion with all participants
12.40-12.45Conclusion and FarewellBianca Hoeben, Utrecht, The Netherlands
13.30-15.30For registered subgroups: practical demonstration VMAT TBI setup in bunker (registration during symposium)Bianca Hoeben, Enrica Seravalli, Mirjam Willemsen-Bosman, Utrecht, The Netherlands
13.30-15.00For registered subgroups: guided tour Princess Máxima Center for pediatric oncology (registration during symposium)

*Virtual presentation to auditorium

Utrecht city

Information regarding Utrecht city -> more information

Practical information


UMC Utrecht

Cancer Center
Heidelberglaan 1003
3584 CX Utrecht
The Netherlands

Hotel information

Hotelservice Utrecht


The symposium takes place in the Auditorium, first floor in the Q-building, room Q.01.226. The auditorium is reached when entering the UMC Utrecht main entrance via the first floor, follow the sign to the Q-building. Or take the entrance in the Q building in the department of Radiotherapy, receptie 2, at Universiteitsweg, and go to the first floor.

Location UMC Utrecht -> directions

Regular tramlines (line 21+22) and bus lines connect the city center to the hospital -> directions

You can exit the tram / bus at stops “UMC Utrecht” or “WKZ / Máxima”

From the airport

You can plan your journey on -> ns travel planner


Refund & cancellation policy

Registration cancellations or substitutions must be received by email to before the 8th of May 2023

No registration refunds will be granted after that date; however, you may transfer your registration to a colleague.


The organizers are not liable for any losses, accidents or damage to persons or objects, regardless of the cause. Participants and accompanying persons attend the conference and all accompanying events at their own risk and responsibility.

Lunch and Dinner

The lunches and coffee/tea will be served near the Auditorium.

On June 5th , a social dinner will be organized in the evening for all participants who wish to join (registration only)

Dinner location is Bar Brasserie Bren, Drieharingstraat 9, in the center of Utrecht


The Total Body Irradiation: from 2D to 3D and beyond. Subtitle: Radiotherapy during myeloablative conditioning for stem cell transplantation, current and future perspectives, Utrecht, Netherlands, 05/06/2023-06/06/2023 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.

Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at

Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.


If you have any questions regarding the meeting, please don’t hesitate to contact us via


The maximum number of 100 registrations has been reached