VMAT and TomoTherapy TBI, TMI and TMLI –
whole-body irradiation in the 21st century

Radiotherapy during myeloablative conditioning for stem cell transplantation, highly conformal planning techniques

Myeloablative Total Body Irradiation (TBI) has since long been a cornerstone of the conditioning for hematopoietic stem cell transplantation (HSCT). Currently, use of TBI is mainly indicated for high-risk hematologic malignancy with allogeneic HSCT. The aspiration to reduce acute and long-term effects has induced changes in HSCT and TBI protocols over time. Institutions have varying site-specific setups and techniques for conventional TBI. An increasing number of centers are implementing highly conformal techniques with VMAT or TomoTherapy. Total Marrow Irradiation (TMI), Total Lymphoid Irradiation (TLI), and Total Marrow and Lymphoid Irradiation (TMLI) target the bone marrow and/or lymphoid volume while reducing doses in the remainder of the body, thereby optimizing the balance between treatment outcome and toxicities.

In the 2025 VMAT and Tomotherapy TBI Teaching Symposium, international experts who have cooperated in the establishment of protocols and scientific publications will take the floor to give presentations regarding current and future perspectives for highly conformal radiotherapy techniques during myeloablative conditioning for HSCT in children and adults. The program will cover diverse aspects of implementation of VMAT and TomoTherapy TBI, TMI and TMLI treatments. There will be breakout sessions for physicists, radiotherapy technologists and radiation oncologists, where we will provide an in-depth focus on technical and clinical aspects of VMAT and TomoTherapy planning and treatment for TBI, TMI and TMLI, for different treatment planning systems and treatment machines.

Moreover, there will be ample room for connection and discussion with international colleagues to exchange experiences during the daytime program and social gatherings on June 16 and 17.

The TBI symposium is of interest for radiation oncologists, medical physicists, radiotherapy technologists, hematologists and anybody with an interest in TBI, TMI and TMLI. We hope to welcome you in Utrecht in June 2025!

Bianca Hoeben

MD PhD, radiation oncologist

UMC Utrecht / Princess Máxima Center,
The Netherlands

Enrica Seravalli

PhD, clinical physicist

UMC Utrecht, The Netherlands

Mirjam Willemsen-Bosman

radiation technologist

UMC Utrecht, The Netherlands

Jeffrey Wong

Professor, MD, radiation oncologist

City of Hope, Duarte, California, USA

Chunhui Han

Clinical Professor, PhD, clinical physicist

City of Hope, Duarte, California, USA

Susan Hiniker

Associate Professor, MD, radiation oncologist

Stanford University, Stanford, California, USA

Nataliya Kovalchuk

Clinical Professor, PhD DABR, clinical physicist

Stanford University, Stanford, California, USA

Jacob Engellau

MD PhD, radiation oncologist

Skåne University Hospital, Lund, Sweden

Per Engström

PhD, clinical physicis

Skåne University Hospital, Lund, Sweden

Cynthia Aristei

Professor, MD PhD, radiation oncologist

University of Perugia and Perugia General Hospital, Perugia, Italy

Simonetta Saldi

MD PhD, radiation oncologist

University of Perugia and Perugia General Hospital, Perugia, Italy

Claudio Zucchetti

clinical physicists

University of Perugia and Perugia General Hospital, Perugia, Italy

Christian Fulcheri

clinical physicists

University of Perugia and Perugia General Hospital, Perugia, Italy

  • Day 1
  • Day 2
08.30 – 09.00Welcome and registration
09.00 – 09.15Welcome
09.15 – 10.00Conformal techniques for TBI, TMI and TMLI; general introductionBianca Hoeben
Susan Hiniker
Jeffrey Wong
Split up into VMAT (1) & Tomotherapy (2) groups
10.00 – 11.00
1. auditorium
Implementation of VMAT TBI / TMI / TMLI in your department;
the commissioning process
Enrica Seravalli
Nataliya Kovalchuk
10.00 – 11.00
2. Van Peperzeel room
Implementation of TBI / TMI / TMLI TomoTherapy in your department; the commissioning processPer Engström
Claudio Zucchetti
Chunhui Han
11.00 – 12.00
1. auditorium
Patient positioning & simulation for conformal VMAT whole-body irradiationMirjam Bosman
Nataliya Kovalchuk
11.00 – 12.00
2. Van Peperzeel room
Patient positioning & simulation for conformal Tomotherapy whole-body irradiationPer Engström
Claudio Zucchetti
Chunhui Han
12.00 – 13.00Lunch
13.00 – 14.00
1. auditorium
Planning basics: VMAT TBI and TM(L)INataliya Kovalchuk
Chunhui Han
Mirjam Bosman
13.00 – 14.00
2. Van Peperzeel room
Planning basics: Tomotherapy TBI and TM(L)IPer Engström
Claudio Zucchetti
Chunhui Han
14.00 – 15.00
1. auditorium
Treatment delivery; QA, positioning, IGRT for VMATEnrica Seravalli
Nataliya Kovalchuk
Bianca Hoeben
14.00 – 15.00
2. Van Peperzeel room
Treatment delivery; QA, positioning, IGRT for TomoTherapyPer Engström
Claudio Zucchetti
Chunhui Han
Jeffrey Wong
Jacob Engellau
Plenary session
15.00 – 15.30Delineation for TBI and TMI and TMLIBianca Hoeben
Jacob Engellau
Cynthia Aristei
Jeffrey Wong
15.30 – 16.00Experience with VMAT TBI in a center: StanfordSusan Hiniker
16.00 – 16.20Coffee/Tea, meet&greet
16.20 – 17.00Experience with TMI and TMLI studies in a center: City of HopeJeffrey Wong
Chunhui Han
19.00 – 22.30Social Dinner in Utrecht city center; Humphrey’s
08.15 – 08.45Coffee/Tea, meet&greet
08.45 – 09.15Patient pre-treatment evaluation and per-treatment monitoring for TBI, TMI and TMLIBianca Hoeben
Jacob Engellau
Cynthia Aristei
Simonetta Saldi
Jeffrey Wong
09.15 – 09.35Experience with TMI in a center: LundJacob Engellau
09.35 – 09.55Experience with TMLI in a center: PerugiaCynthia Aristei
Simonetta Saldi
Breakout sessions 1+2; in-depth interactive sessions for 1) physicists / RTT and 2) clinicians
10.00 – 12.30TomoTherapy planning + treatmentPer Engström
Chunhui Han
Claudio Zuchetti
Planning + treatment with Eclipse for Varian LinacNataliya Kovalchuk
Planning + treatment with Monaco for Elekta LinacMirjam Bosman
Enrica Seravalli
10.00 – 12.30Clinical aspects; TBI indications / outcomes / toxicity / considerations for dose+fractionationBianca Hoeben
Susan Hiniker
Clinical aspects; TMI indications / outcomes / toxicity / considerations for dose+fractionationJacob Engellau
Jeffrey Wong
Clinical aspects; TMLI indications / outcomes / toxicity / considerations for dose+fractionationCynthia Aristei
Simonetta Saldi
Jeffrey Wong
12.30 – 13.30Lunch
13.30 – 15.30Continuation breakout sessions
Meanwhile per group of max 20 people:
In-room demonstration rotatable tabletop patient setup (20’ each, 6 groups)
Plenary
15.30 – 16.00Plenary; summary, last questions & goodbyeWhole faculty

Location

UMC Utrecht Cancer Center
Heidelberglaan 1003
3584 CX Utrecht
The Netherlands

Hotel Information

See the official hotel service page for the symposium

Contact

If you have any questions regarding the meeting, please don’t hesitate to contact us via:

info@tbisymposium.nl

To Utrecht

Travel to Utrecht Central Station from Amsterdam Schiphol Airport by train. Plan your journey

In Utrecht

Regular tramlines (line 21+22) and bus lines connect the city center to the hospital.

You can exit the tram / bus at stops
UMC Utrecht or WKZ / Máxima

UMC Utrecht

The symposium takes place in the Auditorium, first floor in the Q-building, room Q.01.226;
and the Van Peperzeel room. The auditorium is reached when entering the UMC Utrecht main entrance via the first floor. Follow the sign to
the Q-building. Or take the entrance in the Q building in the department of Radiotherapy, reception 2, at Universiteitsweg, and go to the first floor.

Accreditation

The Title: VMAT and TomoTherapy TBI, TMI and TMLI – whole-body irradiation in the 21st century. Subtitle: Radiotherapy during myeloablative conditioning for stem cell transplantation, highly conformal planning techniques, Utrecht, The Netherlands, Netherlands 16/06/2025 – 17/06/2025, has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 11.5 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.
Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at https://dhub.ama-assn.org/pages/applications. Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.

An application for accreditation is made to the European Board for Accreditation in Medical Physics (EBAMP). The EBAMP has been set up by medical physics societies across Europe represented by the European Federation of Organisations for Medical Physics (EFOMP).

Liability

The organizers are not liable for any losses, accidents or damage to persons or objects, regardless of the cause. Participants and accompanying persons attend the conference and all accompanying events at their own risk and responsibility.

Refund & cancellation policy

Refund policy: Registration cancellations or substitutions must be received by email to info@TBIsymposium.nl before the 26th of May 2025.

No registration refunds will be granted after that date; however, you may transfer your registration to a colleague.

Refunds will be granted after the TBI symposium.