Myeloablative Total Body Irradiation (TBI) has since long been a cornerstone of the conditioning for hematopoietic stem cell transplantation (HSCT). Currently, use of TBI is mainly indicated for high-risk hematologic malignancy with allogeneic HSCT. The aspiration to reduce acute and long-term effects has induced changes in HSCT and TBI protocols over time. Institutions have varying site-specific setups and techniques for conventional TBI. Several centers have introduced highly conformal techniques such as VMAT or TomoTherapy. Total Marrow Irradiation (TMI), Total Lymphoid Irradiation (TLI), and Total Marrow and Lymphoid Irradiation (TMLI) target the bone marrow and/or lymphoid volume while reducing doses in the remainder of the body.
While techniques may vary from center to center, several considerations regarding setup, total dose, fractionation and organ shielding are of interest to all specialists who perform TBI. The scarcity of guidelines and low number of treated patients in most centers makes international collaboration and knowledge exchange valuable.
In the 2023 TBI Symposium, international experts who have cooperated in the establishment of protocols and scientific publications will take the floor to give in-depth presentations regarding current and future perspectives for conventional and highly conformal radiotherapy techniques during myeloablative conditioning for HSCT in children and adults. The program will cover clinical, technical and biological issues and considerations that are relevant for the daily practice and ongoing strive for improvement of techniques. Moreover, there will be ample room for connection and discussion with international colleagues to exchange experiences during the daytime program and social gatherings on June 5 and 6.
The TBI symposium is of interest for radiation oncologists, medical physicists, radiotherapy technologists, hematologists and anybody with an interest in TBI. We hope to welcome you in Utrecht in June 2023!
|12.00-13.00||Welcome, Registration and Lunch|
|13.00-13.05||Welcome||Bianca Hoeben, Utrecht, The Netherlands|
|13.05-13.25||History of HSCT and TBI||Marc Bierings, Utrecht, The Netherlands|
|13.25-13.45||Toxicity profiles of TBI, considerations for mitigation||Bianca Hoeben, Utrecht, The Netherlands|
|13.45-14.15||Clinical aspects of conventional TBI approaches and recommendations||Tom Boterberg, Ghent, Belgium|
|14.15-15.00||Technical aspects of conventional TBI approaches and recommendations||Ruud van Leeuwen, Nijmegen, The Netherlands|
|15.30-16.30||VMAT TBI: practical steps from the drawing board to the linac||Bianca Hoeben, Enrica Seravalli, Mirjam Willemsen-Bosman, Utrecht, The Netherlands|
|16.30-17.15||VMAT and Tomotherapy TBI and TMLI: single center experience in >400 pediatric patients||Daria Kobyzeva, Anna Loginova, Moscow, Russia*|
|19.30||Social Dinner Bar Brasserie Bren, Utrecht city center|
|08.30-09.30||TMI and TMLI: clinical studies and experience||Jeffrey Wong, Duarte, CA, USA*|
|09.30-10.30||Radiobiological issues of TBI and TMI; translational and clinical studies||Susanta Hui, Duarte, CA, USA*|
|11.00-11.20||Single center experience with TomoTherapy TMI||Jacob Engellau, Lund, Sweden|
|11.20-11.40||Single center experience with VMAT TLI||Abrahams Ocanto, Madrid, Spain|
|11.40-12.10||TMLI in the conditioning regimen for T-cell depleted hematopoietic stem cell, regulatory and effector T-cell transplantation for acute leukemia. The Perugia experience.||Cynthia Aristei, Simonetta Saldi, Perugia, Italy|
|12.10-12.40||Group discussion: next steps – the future of radiotherapy in HSCT conditioning, collaboration, research needs||Discussion with all participants|
|12.40-12.45||Conclusion and Farewell||Bianca Hoeben, Utrecht, The Netherlands|
|13.30-15.30||For registered subgroups: practical demonstration VMAT TBI setup in bunker (registration during symposium)||Bianca Hoeben, Enrica Seravalli, Mirjam Willemsen-Bosman, Utrecht, The Netherlands|
|13.30-15.00||For registered subgroups: guided tour Princess Máxima Center for pediatric oncology (registration during symposium)|
*Virtual presentation to auditorium
Information regarding Utrecht city -> more information